Vascular malformations

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چکیده

1. Venous malformations: congenital venous anomalies pathologically characterised by anomalous veins (thickened and hyalinised walls) separated by normal brain. These anatomically abnormal veins drain normal brain tissue. It is thought that they result from intrauterine ischemic event occurring during the formation of medullary veins resulting in collateral venous drainage. This is the most common vascular malformation accounting for 65% of all cases. The prevalence in autopsy series up to 2.5%. Most commonly located adjacent to the cortex or in periventricular region. Infratentorial lesions are always in the cerebellum. Most commonly solitary and commonly associated with other vascular malformations particularly cavernomas. The majority are asymptomatic. The risk of haemorrhage if any is minimal (prospective risk in 1 study was 0, 3% per year) and one should always look for another cause of haemorrhage (associated cavernoma). The association with seizures is controversial and rarely do they can thrombose causing infarction. This malformation gives the appearance of caput medusae on angiograms (radially arranged anomalous veins that converge into large draining vein). Surgery is not indicated for these benign lesions and injury to these veins can cause venous infarction. 2. Capillary telangiectasia: The second most common vascular malformation characterised by a tuft of dilated capillaries with normal intervening brain (no gliosis or hemosiderin). The capillaries are normal except for dilatation. They are solitary in 78% of cases and most commonly located in the pons (71%). Grossly look like a small area of petechial haemorrhage. Microscopically there are small tufts of capillaries which are structurally normal. Normal parenchyma is present in between the capillaries. These are angiographically occult lesions not detected on CT or angiogram. MRI-small homogeneously enhancing lesions with loss of signal on gradient echo sequences. These are benign and asymptomatic lesions and usually discovered incidentally at autopsy or on MRI scan and only extremely rarely are associated with haemorrhage and in that case one should look for other cause and treat the ICH as usual. 3. Cavernous angiomas (cavernomas):

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تاریخ انتشار 2009